Effect of treatment with different antibilharzial drugs on renal functions in urinary schistosomiasis
el-Zayadi, A.M.; Shoeb, S.M.; Sabour, M.S.; Basmy, K.
Tropenmedizin und Parasitologie 25(2): 147-152
1974
ISSN/ISBN: 0303-4208 PMID: 4418544 Document Number: 77519
Forty-two male Egyptian patients with Schistosoma haematobium were subjected to renal function tests before and 2 to 3 months after chemotherapy with potassium antimony tartrate, sodium antimony dimercaptosuccinate or niridazole, when 35 had ceased to pass viable ova in urine. The glomerular function tests showed that blood urea, serum creatinine and endogenous creatinine clearance were little affected before treatment and insignificantly altered by it. The tubular function tests revealed that urine concentration was low in 36 patients and treatment improved it in 26; the mean urine concentration was significantly improved from 822.2 plus or minus 199.2 before to 939.6 plus or minus 224.2 mOsm/kg H2O. The first 15-min phenolsulphonphthalein (p.s.p.) excretion was found to be reduced in 20 patients, and treatment improved 15 of them. The urinary dilution test was raised in 18, and treatment improved 7. Urinary acidification was impaired in 10, 5 of whom improved after treatment. It is concluded that early infection produced marked renal functional abnormalities which may be corrected by early treatment; late therapy would probably be ineffective or even hazardous.