Characterization of a suppressive factor of platelet cytotoxic functions in human and rat schistosomiasis mansoni
Pancré, V.; Joseph, M.; Capron, A.; Delanoye, A.; Vorng, H.; Auriault, C.
Clinical and Experimental Immunology 76(3): 417-421
1989
ISSN/ISBN: 0009-9104 PMID: 2526699 Document Number: 331735
It has been demonstrated that mitogen-stimulated CD8+ CD4- T cells from normal donors produce a suppressive lymphokine (PASL) of IgE-dependent platelet cytotoxicity. The production, after antigenic-stimulation, of this suppressive factor was demonstrated during ongoing infections by Schistosoma mansoni in man and in the rat. The T lymphocyte subpopulation producing this factor was also identified as expressing the marker of the suppressive subset. Because of the absence of species restriction, the relevance in vivo of PASL was determined in the rat model. In these conditions there was a complete abolition of the protection normally conferred against a challenge infection by the passive transfer of platelets from immune to normal rats after treatment of transferred platelets with T lymphocyte supernatants.