The additive synthesis of a regulatory peptide in vivo: the administration of a vaccinal Francisella tularensis strain that produces beta-endorphin
Borzenkov, V.M.; Pomerantsev, A.P.; Ashmarin, I.P.
Biulleten' Eksperimental'noi Biologii i Meditsiny 116(8): 151-153
1993
ISSN/ISBN: 0365-9615 PMID: 8274686 Document Number: 7740
It has been shown, that vaccine strain of tularemia microbe, F.T.ISE., which produced recombinant beta-endorphin, when administered to CBA mice. It was shown to increase in the threshold level of pain sensitivity and is associated with peptides associated changes the stereotypic behavior. The observed correlated in time with the pattern of the dynamics of culture in the experimental animals and were associated with the level of recombinant beta-endorphin synthesis.
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