The effect of aerosolization on the changes in major biological properties of the vaccine strain of Francisella tularensis
Koniukhov, V.F.; Petrosov, V.V.; Meshcheriakova, I.S.; Savel'eva, R.A.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 6: 26-29
1983
ISSN/ISBN: 0372-9311 PMID: 6613417 Document Number: 197997
The exposure of F. tularensis vaccine strain 15/10 in the form of aerosol for more than 10 minutes results in the decrease of its virulence, immunogenicity and the content of species-specific antigen and in the increase of the dissociation level. Proceeding from this fact, during aerosol immunization with this vaccine strain exposure must not exceed 5 minutes for unstabilized aerosol and 10 minutes for aerosol stabilized with 5% glycerin. Under these conditions the properties of F. tularensis strain 15/10 are retained practically on the initial level.