The genetic control of antibody binding constants and specificities in inbred rats
Ruscetti, S.K.; Kunz, H.W.; Gill, T.J.
Journal of Immunology 113(5): 1468-1476
1974
ISSN/ISBN: 0022-1767 PMID: 4213909 Document Number: 74268
The binding constants of antibodies to poly (Glu52Lys33Tyr15) from several strains of high- and low-responding rats and their various hybrids were measured. High responders produced antibodies with higher binding constants than low responders. Breeding studies showed that the ability to produce high-affinity antibodies is under genetic control and is linked to the major histocompatibility locus, Ag-B. Precipitin reactions using various synthetic polypeptides indicated that the antibodies produced by the high responders were more cross-reactive than those produced by the low responders. The ability to cross-react appears also to be dominant and linked to the major histocompatibility locus.