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Regional differences in homovanillic acid concentrations after acute and chronic administration of antipsychotic drugs

Bowers, M.G.; Rozitis, A.

Journal of Pharmacy and Pharmacology 26(9): 743-745

1974

ISSN/ISBN: 0022-3573
PMID: 4155758
Document Number: 74167
Rabbits were injected acutely or chronically with chloropromazine (10 mg kg-1, s.c.), thioridazine (10 mg kg-1, s.c.), fluphenazine enanthate (1 mg kg-1, i.m.) or saline. Caudate, limbic and hypothalamic regions were individually assayed for homovanillic acid [HVA]. All acute treatments significantly increased HVA levels in each of the 3 regions when compared to control values. Chronic treatments with each drug also significantly increased HVA levels in each region. Only the caudate nucleus showed a significant reduction in HVA following each of the 3 drugs when acute and chronic treatments were compared.

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