Action of a chronic arecoline administration on mouse motility and on acetylcholine concentrations in the CNS
Molinengo, L.; Fundaró, A.M.; Cassone, M.C.
Journal of Pharmacy and Pharmacology 40(11): 821-822
1988
ISSN/ISBN: 0022-3573 PMID: 2907570 Document Number: 318617
The modifications of mouse motility and of the levels of acetylcholine (ACh) in two sections of the CNS caused by a chronic administration of 4.5; 9.5; 28.5 and 60 mg kg-1 day-1 of arecoline for 20 days have been studied. At low doses (4.5 and 9.5 mg ka-1 day-1), aerocline caused no modification of the ACh levels and of the motility. The higher doses (28.5 and 60 mg kg-1 day-1) caused a reduction of the mouse motility and an increase of the ACh levels in the subcortical structures of the CNS of the mouse.