PAF-induced histamine release in the isolated perfused rat kidney
Alessandrì, M.G.; Giovannini, L.; Mian, M.; Palla, R.; Gattai, V.; Ciangherotti, A.; Bertelli, A.
International Journal of Tissue Reactions 10(1): 33-38
1988
ISSN/ISBN: 0250-0868 PMID: 2456276 Document Number: 318616
The platelet-activating factor (PAF) has been shown to stimulate the release of prostaglandins, leukotrienes and 5HT from a number of cell types. In this work we studied the effects of bolus injections of PAF on the isolated perfused rat kidney. Results showed histological damage at the proximal-tubule level and a significant histamine release.
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