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Regional variation in the histological appearance of the small and large intestine of the rat following acute and chronic administration of Melo's Conquer Mixture

Didia, B.C.; Dapper, D.V.

West African Journal of Medicine 18(2): 110-113

1999

ISSN/ISBN: 0189-160X
PMID: 10504867
Document Number: 505840
The effect of acute and chronic administration of various doses of Melo's Conquer Mixture (MCM) on the histological appearance of the small and large intestine was investigated in albino Wistar rats. Obtained results show that at recommended therapeutic dose, MCM is able to evoke an acute inflammatory response, with infiltration of the mucosa and submucosa by neutrophils, lymphocytes and eosinophils. In addition, there was submucosal lymphoid follicle hyperplasia and increased mucus secreting cells. The severity of these changes were dependent more on prolonged administration than dose. These findings suggest strongly that MCM is a potential toxic agent. We therefore recommend further chemical analysis to identify the possible toxic agent(s) in this mixture.

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