Leukocyte adhesion deficiency disorder: report of one case
Hung, C.H.; Cheng, S.N.; Hua, Y.M.; Wang, C.L.; Chen, Y.H.; Yang, K.D.
Acta Paediatrica Taiwanica 40(2): 128-131
1999
ISSN/ISBN: 1608-8115 PMID: 10910603 Document Number: 7072
In this paper, a case of leukocyte adhesion deficiency disorder confirmed by flow cytometry and leukocyte chemotaxis assays is reported. The 32-day-old female infant was admitted to our ward on account of delayed umbilical cord detachment and omphalitis. After admission, hemogram revealed severe leukocytosis (white blood cell (WBC) counts: 86,800/cumm), and there was poor clinical response to several kinds of antibiotics. The above history indicated that the patient might be a case of leukocyte adhesion deficiency disorder. A definite absence of CD11b/CD18 adhesion molecule on the patient's granulocytes and severe defects of leukocyte function demonstrated by chemotaxis, chemokinesis and zymosan-induced respiratory burst assays confirmed this diagnosis.
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