Preoperative serum intercellular adhesion molecule-1 (ICAM-1) and E-selectin (endothelial cell leukocyte adhesion molecule, ELAM-1) in patients with epithelial ovarian cancer
Ferdeghini, M.; Gadducci, A.; Prontera, C.; Annicchiarico, C.; Gagetti, O.; Bianchi, M.; Facchini, V.; Genazzani, A.R.
Anticancer Research 15(5b): 2255-2260
1995
ISSN/ISBN: 0250-7005 PMID: 8572633 Document Number: 444818
The serum levels of intercellular adhesion molecule-1 (ICAM-1) and E-Selectin (endothelial cell leukocyte adhesion molecule, ELAM-1) were retrospectively measured in serum samples drawn at diagnosis from 66 patients with epithelial ovarian cancer and 128 patients with benign ovarian masses. The preoperative serum ICAM-1 levels were higher in the former group (p lt 0.0001), while serum E-Selectin concentrations were similar in the two groups (p= NS). Among patients with epithelial ovarian cancer, neither serum ICAM-1 nor E-selectin levels correlated with FIGO stage and with histologic type. The serum assay of ICAM-1 and E-Selectin seems to have limited value in the management of patients with epithelial ovarian cancer.