Endothelial and leukocyte adhesion molecules in inflammation and disease
Winn, R.; Vedder, N.; Ramamoorthy, C.; Sharar, S.; Harlan, J.
Blood Coagulation and Fibrinolysis An International Journal in Haemostasis and Thrombosis 9(Suppl 2): S17-S23
1998
ISSN/ISBN: 0957-5235 PMID: 9662466 Document Number: 496813
Injury associated with ischemia and reperfusion is a significant factor in a number of clinical diseases. We have completed a number of preclinical studies investigating the blockade of leukocyte adhesion molecules in ischemia-reperfusion injury. In our work and in the work of other investigators, monoclonal antibodies directed to CD18, P-selectin and L-selectin were effective in reducing ischemia-reperfusion injury to the rabbit ear and in reducing injury following hemorrhagic shock in both rabbits and nonhuman primates. Ischemia-reperfusion injury was also reduced by synthetic oligosaccharide sLe(x). These studies suggest that adhesion blockade might be effective in the clinical setting.