HIV infection and related neoplasms: A case series and literature review
Aponte, I.; Caceres, W.; Baez, L.; Maldonado, A.; Montalvo, L.
Boletin de la Asociacion Medica de Puerto Rico 91(1-6): 37-45
1999
ISSN/ISBN: 0004-4849 Document Number: 703019
Immunosuppressed persons are at greater risk of developing malignancies. A variety of malignancies have been reported to be related to the HIV disease. We retrospectively analyzed the incidence, pathological diagnosis and clinical manifestations in 229 consecutive patients with HIV in the San Juan VA Hospital from November 1994 to August 1998. Ali the patients in the study were men. The patients clinicopathologic and laboratory characteristics were recorded. The most common malignancies encountered were Kaposi's sarcoma (KS) and NonHodgkin's lymphoma (NHL). A review of these neoplasms, commonly and clearly associated to the HIV immunosuppression, was performed. Infectious agents have been suggested to contribute to the etiology of KS. The only of these agents to be found consis-tently in all forms of the disease is the HHV-8. The manage-ment of these lesions involves either local or systemic treat-ment. Finally, as HIV-infected patients live longer, more cases of HIV-related lymphoma could be expected. It is hoped that further understanding about the etiology and pathogenesis of these lymphomas will unveil newer thera-peutic approaches to this disease.
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