Metabolic control of food intake
Friedman, M.I.
Boletin de la Asociacion Medica de Puerto Rico 81(3): 111-113
1989
ISSN/ISBN: 0004-4849 PMID: 2712967 Document Number: 700542
A specific biochemical mechanism for the metabolic control of food intake has not been identified. However, a theory based on a signal generated from the oxidation of metabolic fuels and detected in the liver offers a powerful, integrative framework that helps explain a number of phenomena related to feeding behavior. In addition to providing a metabolic basis for the formation of conditioned food flavor preferences, a control of food intake by fuel oxidation provides a mechanism for overeating in the dynamic phase of obesity and hyperphagia produced by high-fat diets.
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