Metabolic oscillations and food intake
Allred, J.B.; Roehrig, K.L.
Federation Proceedings 32(6): 1727-1730
1973
ISSN/ISBN: 0014-9446 PMID: 4351099 Document Number: 69444
This is a review of the evidence that fat metabolism is closely regulated by food intake and of the possible mechanisms by which such regulation occurs. Higher animals eat only intermittently but have a continuous demand for substrate at cellular level and nutrients must be stored during periods of alimentation for use during periods of food deprivation. This results in oscillatory behaviour of carbohydrate and lipid metabolism in the liver, both of which are rapidly influenced by changes in food intake. There are indications that cyclic-3',5'-adenosine monophosphate (cyclic AMP) plays a regulatory role in liver lipogenesis as it does in glycogen metabolism. It is proposed that cyclic AMP is a part of the messenger system by which the major metabolic processes are rapidly regulated by food intake.