A Case of Breast Cancer Liver Metastases with Jaundice Responding to Chemotherapy
Kinoshita, H.; Teraoka, H.; Mori, T.; Hasegawa, T.; Noda, E.; Takashima, T.; Hirakawa, K.; Ohira, M.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 46(13): 2461-2463
2019
ISSN/ISBN: 0385-0684 PMID: 32156965 Document Number: 699742
A 50-year-old woman was referred to our hospital due to breast cancer with multiple liver metastasis diagnosed by CT scan. Laboratory findings showed liver dysfunction(T-Bil 7.6mg/dL)with marked elevation of tumor markers(CEA 727.9 ng/mL). Breast tumor biopsy showed an invasive ductal carcinoma(scirrhous type), ER(+), PgR(-), and HER2(3+). Combination therapy with docetaxel, carboplatin and, trastuzumab was administered after the end of 1 course of weekly paclitaxel plus bevacizumab regimen. The patient maintained a good condition without liver dysfunction 8 months after the first visit. Follow-up CT scan showed partial response of breast and hepatic tumors. Our case suggests that careful chemotherapy can improve the prognosis of breast cancer with liver metastasis even if a patient is in an icteric condition.