Effects of topical application of doxycycline on avulsed permanent teeth
Liu, Y.; Zhu, Z.; Sun, C.-W.; Sun, J.-J.; Zhu, M.-Y.
Shanghai Kou Qiang Yi Xue 28(6): 640-643
2019
ISSN/ISBN: 1006-7248 PMID: 32346711 Document Number: 699444
To evaluate the treatment effect of topical doxycycline on avulsed permanent teeth compared with normal saline. A total of 44 avulsed teeth from 38 patients (22 boys and 16 girls, aged 7-14 years) were recruited. Twenty-one teeth in group A were treated with doxycycline for 5 min before replantation while 23 teeth in group B were treated with saline solution. All participants were followed up for at least 12 months. The clinical outcome differences between 2 groups was evaluated by Mann-Whitney U test. In group A, 18 teeth were found pulp necrosis, 3 with infection-related resorption, 13 with ankylosis-related resorption and 6 were extracted. In group B, 16 were diagnosed with pulp necrosis, 4 with infection-related resorption, 12 with ankylosis-related resorption and 7 were extracted. No significant differences were found between the two groups on pulp survival and periodontal healing. Compared with treatment with normal saline, avulsed permanent teeth treated with doxycycline did not show a better clinical outcome.