The effects on accommodative and pupillary responses by topical application of cyclopentolate hydrochloride
Ohmi, G.; Kinoshita, H.; Kinoshita, S.
Nippon Ganka Gakkai Zasshi 95(11): 1099-1104
1991
ISSN/ISBN: 0029-0203 PMID: 1759650 Document Number: 769
Accomodative and pupillary responses, refractive change, and visual acuity after 30 .mu.l instillation of cyclopentlate hydrochloride of various concentrations (0.00625.apprx.0.1%) in 6 young normal males (27.0 .+-. 0.6 yrs) were investigated. Both accommodative and pupillary responses were measured by an infrared optometer, at pre-instillation and 1, 3, 6, 9 and 24 hours post-isstillation. No significant effects were induced by concentrations of cyclopentlate hydrochloride 0.0125% or less. Reduced amplitude of accommodation and enlarged pupil were, however, observed by 0.025% and 0.05% of cyclopentlate hydrochloride from 1 through 9 hours post-instillation. Miotic response in accommodation was also reduced from 1.apprx.6 hours at the same concentrations. A concentrations of 0.1% cyclopentlate hydrochloride showed both reduction of accommodation amplitude and enlarged pupil for 24 hours after instillation. However, neither refraction nor visual acuity was affected by any concentration of cyclopentlate hydrochloride. The results suggest that cytopentlate hydrochloride at concentrations up to 0.05% applied before sleep would not be accompanied by inhibitory effects on accommodation during the day.
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