Transmitted drug resistance among HIV infected men who have sex with men in Tianjin, 2014-2017
Zheng, M.N.; Ning, T.L.; Zhou, N.; Zhao, X.; Li, L.; Zhu, J.J.; Cheng, S.H.
Zhonghua Liu Xing Bing Xue Za Zhi 39(5): 619-624
2018
ISSN/ISBN: 0254-6450 PMID: 29860805 Document Number: 697373
目的： 了解2014－2017年天津市MSM人群HIV感染者（MSM感染者）原发性耐药（transmitted drug resistance，TDR）的流行特点和相关因素。 方法： 收集2014－2017年天津市未经抗病毒治疗的MSM人群中HIV感染者的血浆样本共225例，采用巢式PCR法扩增pol区基因片段，进行基因型耐药检测和相关因素分析。 结果： 205例样本获得pol区基因序列，完成HIV亚型和耐药检测。基因型依次为CRF01_AE占53.2%（109/205），CRF07_BC占28.8%（59/205），B亚型占10.2%（21/205），CRF55_01B亚型占4.9%（10/205），其他独特型二代重组亚型占2.9%（6/205）。75例样本成簇分布在20个传播簇内，62.5%（10/16）的TDR样本分布在5个传播簇中。耐药株的TDR流行率为7.8%，2014－2017年每年的TDR流行率逐年上升，分别为3.9%（2/51）、5.7%（3/53）、9.6%（5/52）和12.2%（6/49），但差异无统计学意义（χ(2)=2.504，P=0.127），CRF01_AE亚型和B亚型TDR流行率最高，分别为3.4%（7/205）和2.9%（6/205）。TDR突变以非核苷酸反转录酶抑制剂（NNRTIs）为主，TDR流行率为6.3%（13/205），核苷酸反转录酶抑制剂（NRTIs）和蛋白酶抑制剂（PIs）的TDR流行率分别为1.5%（3/205）和1.0%（2/205）。 结论： 天津市MSM感染者的TDR毒株的TDR流行形势较严重，需采取有针对性的预防和控制措施。.
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