Surveillance of transmitted HIV-1 drug resistance in Gauteng and KwaZulu-Natal Provinces, South Africa, 2005-2009
Hunt, G.M.; Ledwaba, J.; Basson, A.E.; Moyes, J.; Cohen, C.; Singh, B.; Bertagnolio, S.; Jordan, M.R.; Puren, A.; Morris, L.
Clinical Infectious Diseases An Official Publication of the Infectious Diseases Society of America 54 Suppl. 4: S334-S338
2012
ISSN/ISBN: 1537-6591 PMID: 22544199 DOI: 10.1093/cid/cir1017Document Number: 565213
Surveillance of human immunodeficiency virus type 1 transmitted drug resistance (TDR) was conducted among pregnant women in South Africa over a 5-year period after the initiation of a large national antiretroviral treatment program. Analysis of TDR data from 9 surveys conducted between 2005 and 2009 in 2 provinces of South Africa suggests that while TDR remains low (<5%) in Gauteng Province, it may be increasing in KwaZulu-Natal, with the most recent survey showing moderate (5%-15%) levels of resistance to the nonnucleoside reverse transcriptase inhibitor drug class.