Changes in Mac Antibody Levels before and after Surgery and at the time of Relapse/Recurrence in Mac Lung Disease--Can Mac Antibodies be an Indicator of Postoperative Relapse/Recurrence?
Yamada, K.; Kawasumi, Y.; Yasuda, A.; Seki, Y.; Adachi, T.; Tarumi, O.; Hayashi, Y.; Nakagawa, T.; Yamada, N.; Ogawa, K.
Kekkaku 91(2): 41-44
2016
ISSN/ISBN: 0022-9776 PMID: 27263223 Document Number: 689483
Patients receiving surgical treatment for Mycobacterium avium complex (MAC), lung disease should be followed up with careful attention paid to relapse/recurrence, but there is some debate regarding the findings based on which relapse/recurrence should be diagnosed. We hypothesized that we might be able to use anti-GPL core IgA antibodies (MAC antibodies), which have been attracting attention as a factor that may support diagnosis of MAC lung disease, to diagnose postoperative relapse/recurrence. Therefore, we compared the levels of these antibodies before and at the time of relapse/recurrence, and also compared antibody titers before and after surgery. MAC antibody titers were elevated by an average of about 50% at the time of relapse/recurrence compared to those before relapse/recurrence for 6 patients. In contrast, MAC antibody titers were about 30% lower after surgery compared to those before surgery for 37 patients. It may be possible to use MAC antibodies as an indicator of postoperative relapse/recurrence for MAC lung disease.