Allogeneic BMT vs. chemotherapy in late bone marrow relapsed childhood non-T/non-B ALL: results of BFM ALL relapse studies. BFM Relapse Study Group
Schmid, H.; von Schenck, U.; Hartmann, R.; Borgmann, A.; Henze, G.
Bone Marrow Transplantation 18(Suppl 2): 28-30
1996
ISSN/ISBN: 0268-3369 PMID: 8932794 Document Number: 462227
In first BM relapsed non-T/non-B ALL, the outcome is not significantly different after radio-chemotherapy compared with allogeneic BMT. Therefore, radio-chemotherapy is convenient af first late BM relapse and BMT may be performed not before a second BM relapse had occurred. Only a small subgroup of children with isolated BM relapse and peripheral blast cells > or = 10,000/microliter at diagnosis of first relapse has a dismal prognosis after radio-chemotherapy and might benefit from BMT.
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