Increasing risk of relapse after allogeneic stem cell transplant for adult acute lymphoblastic leukemia in > or = 2nd complete remission induced by highly intensive chemotherapy
Mengarelli, A.; Iori, A.Paola.; Cerretti, R.; Cerilli, L.; Romano, A.; Arcese, W.
Haematologica 87(7): 782-784
2002
ISSN/ISBN: 0390-6078 PMID: 12091136 Document Number: 547001
From this retrospective single center analysis adults with acute lymphobalstic leukemia transplanted in gtoreq2nd CR from an HLA-identical sibling later than 1993 had a worse outcome. As the transplanted-related mortality improved by time, this result was essentially due to the increased relapse rate. The intensity of the pre-transplant salvage chemotherapy was identified as the main factor influencing the post-transplant relapse-risk.
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