The Long Non-Coding RNA Associated with Cancerogenesis: Biological Significance and Perspectives of Application in Diagnostic
Kit, O.I.; Kirichenko, E.Y.; Kirichenko, Y.G.; Novikova, I.A.; Selyutina, O.N.; Filippova, S.Y.
Klinicheskaia Laboratornaia Diagnostika 61(1): 13-16
2016
ISSN/ISBN: 0869-2084 PMID: 27183723 Document Number: 689341
The last decade is characterized by development of such technologies as RNA-sequencing and biochips which resulted in discovery of new perspective biomarkersfor personalized diagnostic of cancer. Among them, the long non-coding RNA (IncRNA) are of special interest because according the recent studies they are positioned as important regulators of gene expression on epigenetic, transcription and post-transcription levels. The review considers the role of long non-coding RNA in cancerogenesis. The corresponding of their application in diagnostic is evaluated. A number of examples ofperspective diagnostic and prognostic markers. Their degree of implementation in oncological practice is discussed.