Low expression of long non-coding RNA-LET can indicate metastasis and a poor prognosis: a meta-analysis
Liu, F.; Ou, Y.; Lin, Q.S.; Qiu, C.; Luo, H.L.; Zhu, P.Q.
Minerva Medica 2016
2016
ISSN/ISBN: 0026-4806 PMID: 26842764 Document Number: 688458
Recent studies have reported that the lncRNA-LET was down-regulated in several cancers.The current meta-analysis aims to determine whether lncRNA-LET can be used as a potential biomarker for metastasis and prognosis. We collected all relevant papers by searching multiple electronic databases(Pubmed,EMBASE,Google Scholar,CNKI,Wanfang database) and explored the association between the expression levels of lncRNA-LETand lymph node metastasis (LNM),distant metastasis (DM) and overall survival (OS). A total of 383 patients from four studies were finally included.The meta-analysis results showed that LNM occurred more frequently in patients with low lncRNA-LET expression group than in patients with high lncRNA-LET expression group(OR=4.56,95%CI:2.92-7.12,p<0.00001),and a similar result was observed between lncRNA-LET expression and DM,the OR was 4.77(95%CI:2.29-9.94, p<0.0001).Additionally,we found that patient with low lncRNA-LET expression had a poorer OS than those high lncRNA-LET expression (HR=2.39,95 %CI:1.57-3.21,p = 0.000). LncRNA-LETmay serve as a common molecular marker for metastasis and prognosis in human cancers.