The relation between the low T3 syndrome in the clinical course of myocardial infarction and heart failure
Frączek, M.M.; Gackowski, A.; Przybylik-Mazurek, E.; Nessler, J.
Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 40(240): 380-383
2016
ISSN/ISBN: 1426-9686 PMID: 27403906 Document Number: 688459
It has been proven that either excess or deficiency of thyroid hormones has harmful influence on the cardiovascular system function. On the other hand, severe systemic conditions like myocardial infarction or severe heart failure may affect thyroid hormones secretion and their peripheral conversion, leading to low T3 syndrome. Amongst many mechanisms causing T4 to T3 conversion disturbances, important role plays decreased activity of D1 deiodinase and increased activity of D3 deiodinase. The animal research confirmed that thyroid hormones influence cardiomiocytes phenotype and morphology. They inhibit inflammation, apoptosis and cardiac remodelling after myocardial infarction. It was also proven that free triiodothyronine similarly to brain natriuretic peptide predict long-term prognosis in chronic and acute heart failure patients. Potential influence of low T3 syndrome on the course of myocardial infarction and heart failure may have significant impact on the future research on individualization of myocardial infarction and heart failure treatment depending on patient's thyroid status.