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Evaluation of the Synthesis and Structure of new Azetidin-2-Ones of Ferulic Acid

Stan, C.ăt.ăl.D.; Drăgan, M.; Pânzariu, A.; Profire, L.ţa.

Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 120(2): 434-438

2016

ISSN/ISBN: 0048-7848
PMID: 27483731
Document Number: 686851
To synthesize some new azetidin-2-ones of ferulic acid and to evaluate them from physicochemical and spectral point of view. The synthesis was carried out in several steps: (i) obtaining the ferulic acid chloride; (ii) obtaining the ferulic acid hydrazide with hydrazine hydrate (98%); (iii) condensation of ferulic acid hydrazide with different benzaldehydes (2-hydroxy-/2-nitro-/4-chloro-/4- fluoro-/4-bromo-benzaldehyde) in order to obtain the corresponding hydrazones; (iv) cy- clization of ferulic acid hydrazones with chloroacethyl chloride in freshly distilled toluene medium and in the presence of triethylamine, resulting in the corresponding azetidin-2-ones. Six new azetidin-2-ones of ferulic acid were synthesized. They were characterized in terms of their physicochemical properties and their structure was confirmed by IR and 1H-NMR spectroscopy. Six new azetidin-2-ones of ferulic acid were synthesized, physicochemically characterized and validated spectrally. A

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