Biochemical markers of early diagnosis of occupationally related arterial hypertension in workers of ore-dressing production
Zemlyanova, M.A.; Zaitseva, N.V.; Shlyapnikov, D.M.; Markovich, N.I.
Meditsina Truda i Promyshlennaia Ekologiia 8: 20-25
2016
ISSN/ISBN: 1026-9428 PMID: 30351751 Document Number: 686700
The authors demonstrate that work conditions for main occupations of sylvinite ore-dressing production (drying machine operator, granulation operator, drying and granulation dosage department operator, centrifuge operator, filtration operator, transporting machine operator in drying and granulation department, mill operator) are characterized by combined exposure to chemical and physical occupational hazards: formaldehyde, highly dispersed dust (PM,0), industrial noise, increased microclimate parameters. The work conditions are considered as hazardous (class 3.1, 3.2, 3.3). Findings are reliable increase of MDA level with lower general antioxidant defence in serum, when compared to the reference group. Increased homocysteine, lipoprotein with significant decreased nitrogen oxide production are seen. These processes can result in disordered structure and endothelial function of vessels, with higher prevalence of arterial hypertension. Values of MDA, antioxidant activity, homocysteine, lipoprotein (a), nitrogen oxide are justified as markers for early diagnosis of occupationally related arterial hypertension.