Pathogenetic aspects of occupationally related disorders of lipid metabolism in workers exposed to chemicals
Kudaeva, I.V.; Rukavishnikov, V.S.
Meditsina Truda i Promyshlennaia Ekologiia 4: 13-19
2014
ISSN/ISBN: 1026-9428 PMID: 25051668 Document Number: 675124
The article presents results of lipid metabolism parameters in long-standing examinations of workers exposed to toxic chemicals. Findings are pro-atherosclerotic tendencies that can be considered as occupationally related, their pathogenetic mechanisms are specified. Evidences are that irrespective of acting toxic factor (mercury, vinyl chloride, complex of toxic chemicals) sequence of cholesterol metabolism disorders with pro-atherogenous features in workers has common aspects: at first, high-density lipoproteins cholesterol level lowers and atherogenicity index increases, then general cholesterol level increases, and low-density lipoproteins cholesterol level increases afterwards. Peculiarity is that chronic occupational exposure to vinyl chloride and toxic combustion products causes very low-density lipoproteins involvement into atherogenic process. Lipid metabolism disorders in workers exposed to neurotoxic chemicals at work appeared to progress into psycho-neurologic sphere changes, to have pro-atherogenic tendency and to cause early atherosclerosis, arterial hypertension and ischemic heart disease.