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Changes in biochemical parameters of erythrocytes in workers engaged in pyromellitic dianhydride production

Shakirov, D.F.; Kamilov, F.Kh.; Farkhutdinov, R.R.; Likhovskikh, V.A.

Meditsina Truda i Promyshlennaia Ekologiia 1998(9): 22-26

1998

ISSN/ISBN: 1026-9428
PMID: 9821385
Document Number: 489109
The article presents data of research concerning levels of adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), activity of Na, K- and Ca, Mg-dependent adenosine triphosphatases, glucose-6-phosphate dehydrogenase, concentrations of sodium, potassium, calcium, magnesium and phosphorus in workers contacting some chemicals (pseudocumene, durene, dioxane-1,4, pyromellitic dianhydride, etc.) at work. All examinees were divided into 3 groups in consideration with intensity of chemical exposure: group 1--workers free of the exposure, group 2--workers exposed to the chemicals 2-3 times a week, group 3--workers exposed to the chemicals constantly at work during 3-5 years. Healthy individuals having no occupational exposure to the chemicals formed a reference group. Members of the groups 2 and 3 demonstrated lower levels of ATP, potassium, magnesium, calcium, decreased activity of Ca, Mg-dependent adenosinetriphosphatase and higher levels of ADP, AMP, Na, P and increased activity of Na, K-dependent adenosinetriphosphatase and glucose-6-phosphate dehydrogenase.

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