Inhalation toxicity of nanodispersed manganese oxide aerosol
Zvezdin, V.N.; Zemlyanova, M.A.; Akafieva, T.I.
Meditsina Truda i Promyshlennaia Ekologiia 12: 13-16
2015
ISSN/ISBN: 1026-9428 PMID: 27024922 Document Number: 685475
The article presents results of experimental study concerning acute inhalation toxicity of nanodispersed manganese oxide widely used in novelty goods production. During the technology process, nano-dimensional manganese oxide aerosol could appear in workplace air--that causes danger of the workers' inhalation exposure. Findings are that the studied substance is a nanomaterial with prevalent fihiform particles measuring 15-29 nm. The substance is acutely toxic when inhaled as an aerosol. Cl₅₀ for 4-hour exposure for Wistar rats equals 120 mg/m³ (1 jeopardy class). Clinical manifestations of acute intoxication are mostly irritative and neurotoxic effects supported by morphologic studies. Histopathologic changes in brain tissue are cerebellar ischemia with dilated perecellular spaces, faveolate appearance.