Studies on the onset of effect of reproterol following inhalation from a metered aerosol
Mándi, A.; Wilde, W.; Galgóczy, G.; Aurich, R.; Galambos, E.
Arzneimittel-Forschung 27(12): 64-66
1977
ISSN/ISBN: 0004-4172 PMID: 576834 Document Number: 113033
According to a uniform trial procedure, the broncholytic efficacy of the new beta2-adrenergic 7-(3-[2-(3,5-dihydroxyphenyl)-2-hydroxy-ethylamino]-propyl)-theophylline (reproterol, Bronchospasmin) was tested in a total of 21 patients afflicted with airways obstruction in two lungfunction laboratories. The IGV, Ras and SGaw were calculated by bodyplethysmography before and 1,3 and 5 min following of 2 puffs from an aerosol container. Excellent and highly significantly bronchodilation was shown already 1 min post inhalation, which further increased during testing time and with which results of subjective criteria for dyspnoeic changes correspond. The preparation may therefore be recommended for therapy of dyspnoeic attacks in an aerosol form equipped with metering valves.