Distribution of hydroxycamptothecin after aerosol inhalation in rabbits
Chen, J.; Fang, Y.; Zhang, H-xia.; Huang, L-li.; Qian, X-ping.; Liu, B-rui.
Yao Xue Xue Bao 39(9): 747-751
2004
ISSN/ISBN: 0513-4870 PMID: 15606028 Document Number: 568282
Aim To investigate the tissue distribution and pharmacokinetics of hydroxycamptothecin (HCPT) after aerosol inhalation in rabbits. Methods RP-HPLC was used to determine the concentration of HCPT in different tissues and plasma of rabbits. The tissue distribution of HCPT after aerosol inhalation or iv administration was compared. The plasma concentrations at different time after aerosol inhalation were compared with iv injection. Results The HCPT concentrations in lung after aerosol inhalation at 0.5, 1 and 2 h were 13.52, 27.81 and 20.82 times higher than that of iv administration group, respectively. At the same time, concentrations in other tissues were decreased obviously. The absolute bioavailability of HCPT after aerosol inhalation was 7.38%. Conclusion After aerosol inhalation, HCPT is retained mostly in lung. So this administration route can raise the therapeutic index and reduce adverse effects.