A Case of Taxane-Pretreated Metastatic Gastric Cancer with Excellent Response to Nab-Paclitaxel
Kawabata, R.; Kimura, Y.; Kawase, T.; Yoshikawa, M.; Kameda, C.; Matsumura, T.; Koga, C.; Murakami, M.; Hirota, M.; Noura, S.; Ikenaga, M.; Shimizu, J.; Hasegawa, J.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 42(12): 2088-2090
2015
ISSN/ISBN: 0385-0684 PMID: 26805273 Document Number: 680561
We present a rare case of taxane-pretreated metastatic gastric cancer with an excellent response to nab-paclitaxel. A 66- year-old woman was diagnosed with Stage Ⅳ gastric adenocarcinoma (T4aN3M1[LYM, OTH]P1CY1). She failed to respond to multiple chemotherapeutic regimens including S-1, capecitabine, cisplatin, L-OHP, paclitaxel, docetaxel, and CPT- 11. Finally, 6th line chemotherapy with nab-paclitaxel was tried. After 4 courses of nab-paclitaxel, a CT scan revealed decreasing ascites and a reduction in the size of the ovary metastasis. She experienced a clinical response for about 4 months. The adverse events were only Grade 1 peripheral sensory neuropathy and joint pain, and her performance status improved during the treatment period.