A case of advanced gastric cancer in which the serum HER2-ECD level could be used as a biomarker
Terakawa, H.; Oyama, K.; Watanabe, T.; Tsukada, T.; Okamoto, K.; Kinoshita, J.; Furukawa, H.; Makino, I.; Nakamura, K.; Hayashi, H.; Inokuchi, M.; Nakagawara, H.; Miyashita, T.; Tajima, H.; Takamura, H.; Ninomiya, I.; Kitagawa, H.; Fushida, S.; Fujimura, T.; Ohta, T.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 41(4): 491-493
2014
ISSN/ISBN: 0385-0684 PMID: 24743367 Document Number: 677335
An 83-year-old woman was diagnosed as having advanced gastric cancer with multiple lymph node and hepatic metastases. Histopathological examination revealed that the tissue was human epidermal growth factor receptor 2(HER2)positive. The patient underwent gastrojejunostomy to improve stomach obstruction. Thereafter, S-1 and trastuzumab combination chemotherapy was administered as first-line treatment; irinotecan(CPT-11), cisplatin, and trastuzumab combination chemotherapy, as second-line treatment; and docetaxel plus trastuzumab combination chemotherapy, as third-line treatment. Although both primary and metastatic lesions decreased in size temporarily, their size increased again, and the patient died 1 year and 7 months later. The level of serum HER2-extracellular domain(ECD)was a valuable indicator of response to chemotherapy. Thus, serum HER2-ECD could be a useful biomarker for HER2-positive gastric cancer.