Synthesis of a fluorescent analog of methotrexate lipophilic prodrug
Ylasenko, Y.V.; Alekseeva, A.S.; Vodovozova, E.L.
Bioorganicheskaia Khimiia 40(1): 125-128
2014
ISSN/ISBN: 0132-3423 PMID: 25898731 Document Number: 672167
A fluorescent analog of the lipophilic prodrug of antitumor agent methotrexate has been synthesized. The conjugate consists of a residue of rac-1-[13-(Me4-BODIPY-8)tridecanoyl]-2-oleoylglycerol connected to methotrexate by ester bond via β-Ala-N-carbonylmethylene linker (Me4-BODIPY-8,4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacen-8-yl). The probe is designed for incorporation in the membrane of liposomal vehicle to study a mechanism of interaction with tumor cells and an intracellular traffic.
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