Major non-ABO incompatibility caused by anti-Jk (a) in a patient before allogeneic hematopoietic stem cell transplantation
Kim, M.Y.; Chaudhary, P.; Shulman, I.A.; Pullarkat, V.
Immunohematology 29(1): 11-14
2013
ISSN/ISBN: 0894-203X PMID: 24046917 Document Number: 671219
A 49-year-old white man with blood group AB, D+ was found to have alloanti-Jk(a) and -K when he developed a delayed hemolytic transfusion reaction before allogeneic hematopoietic stem cell transplant (HSCT). Given that his stem cell donor was blood group O, D+, Jk(a+), K-, rituximab was added to his conditioning regimen of fludarabine and melphalan to prevent hemolysis of engrafting Jk(a+) donor red blood cells. The patient proceeded to receive a peripheral blood stem cell transplant from a matched unrelated donor with no adverse events. To our knowledge, this is the first case of successful management of major non-ABO incompatibility caused by anti-Jk(a) in a patient receiving an allogeneic HSCT reported in the literature.