The incidence of hemorrhagic cystitis and BK-viruria in allogeneic hematopoietic stem cell recipients according to intensity of the conditioning regimen
Giraud, Géraldine.; Bogdanovic, G.; Priftakis, P.; Remberger, M.; Svahn, B-Marie.; Barkholt, L.; Ringden, O.; Winiarski, J.; Ljungman, P.; Dalianis, T.
Haematologica 91(3): 401-404
2006
ISSN/ISBN: 0390-6078 PMID: 16531266 Document Number: 598509
The influence of BK-viruria, donor background, and conditioning on the development of hemorrhagic cystitis was examined in 90 allogeneic hematopoetic stem cell transplant patients, of whom 15 developed hemorrhagic cystitis. Thirty-two patients had related and 58 had unrelated donors, while 44 received full, and 46 received reduced intensity conditioning (RIC). BK-viruria was more common in patients with hemorrhagic cystitis than in those without (p<0.01), and hemorrhagic cystitis was less common in patients with related donors than in those with unrelated donors (p=0.02). Finally, hemorrhagic cystitis and BK-viruria were less common in patients receiving RIC, rather than full conditioning (p<0.01 and p<0.01, respectively).