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The feasibility of reduced-intensity allogeneic hematopoietic stem cell transplantation from a related donor with HLA one-antigen with or without one-allele mismatch

Nakai, K.; Mineishi, S.; Kami, M.; Kanda, Y.; Tanosaki, R.; Takaue, Y.

Haematologica 88(1): 115-117

2003

ISSN/ISBN: 0390-6078
PMID: 12551837
Document Number: 562322
It is still unclear whether reduced-intensity stem cell transplantation (RIST) from an HLA-mismatched related donor is feasible for hematologic malignancies. In the current study on the use of antithymocyte globulin (ATG) in 13 patients, we focused on this issue by evaluating regimen-related toxicities, engraftment, graft-versus-host disease (GVHD), infection, and overall survival. Our results suggest that this procedure may be acceptable for patients without a matched related donor.

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