Establishment of modern multi-component sustained-release preparations of oral traditional Chinese medicines
Xia, H.-J.; Zhang, Z.-H.; Liu, D.; Yu, D.-H.; Jia, X.-B.
Zhongguo Zhong Yao Za Zhi 38(19): 3400-3404
2013
ISSN/ISBN: 1001-5302 PMID: 24422416 Document Number: 665882
Traditional Chinese medicines have a long history, with a large quantity of efficient traditional Chinese medicines and prescriptions. However, the vast majority of pharmaceutical dose forms remain common preparations, with very few efficient, long-lasting and low-dose preparations. The sustain-release preparation allows sustained drug release in a longer period of time, maintains blood drug concentration, reduces the toxic effect and medication frequency, and improves medication compliance. Unlike monomer drugs, the material base of traditional Chinese medicine and compounds is multi-component, instead of single or several active monomers. Therefore, under the guidance of the Chinese medicine theories, modern multi-component sustained-release preparations were developed for oral traditional Chinese medicines, with the aim of finally improving the clinical efficacy of traditional Chinese medicines.