Cutaneous adverse drug reactions: clinical aspects and identification
Kardaun, S.H.
Nederlands Tijdschrift Voor Geneeskunde 157(11): A5823
2013
ISSN/ISBN: 1876-8784 PMID: 23484517 Document Number: 665883
Clinically, mucocutaneous adverse drug reactions are very variable and heterogenic. As they may strongly resemble other clinical pictures they regularly constitute a diagnostic challenge. Moreover, skin manifestations may mirror adverse drug reactions in other organs. Risk factors for cutaneous adverse reactions can be drug- or patient-related and are not always known. Cutaneous adverse drug reactions are usually mild and transient, but they can also be severe or life-threatening. Early recognition and adequate management is the key to preventing progression and restoring health. Supportive therapy may help to reduce the symptoms. Distinguishing between allergic and non-allergic reactions is important in deciding whether to withdraw the suspected medication. Confirming a suspected cutaneous drug reaction necessitates a stepwise approach. The strategy is focused on recognition and characterisation of the reaction pattern, and identification of the suspected medication, followed by adequate management.