Effects of long-term treatment with depot medroxy progesterone acetate for contraception on estrogenic activity
Taneepanichskul, S.; Patrachai, S.
Journal of the Medical Association of Thailand 81(12): 944-946
1998
ISSN/ISBN: 0125-2208 PMID: 9916381 Document Number: 6653
This article evaluates the effects of long-term treatment with depot-medroxyprogesterone acetate (DMPA) by measuring the serum estradiol level and estrogenic activity. A total of 50 healthy women, aged 24-48 years, who had been using 150 mg injection of DMPA every 12 weeks for contraception for a minimum period of 36 months and who had attended the Family Planning Clinic at Ramathibodi Hospital, Bangkok, from January 1, 1996, to December 31, 1996, were interviewed. From the study it was found that the mean duration of DMPA use was 59.1 +or- 30.7 months and the mean serum estradiol level was 52.7 +or- 15.1 pg/ml. Considering the possible symptoms related to estrogen reduction, these women did not have problems with vaginal dryness, hot flushes or night sweating. In conclusion, the study revealed that long-term DMPA acceptors had no symptoms of estrogen deficiency and their serum estradiol levels were well above those of postmenopausal women.
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