Effects of heavy and deuterium-depleted water on vascular reactivity
Haulică, I.; Peculea, M.; Stefănescu, I.; Tiţescu, G.; Todiraş, M.; Bild, W.
Romanian Journal of Physiology 35(1-2): 25-32
1998
ISSN/ISBN: 0035-399X PMID: 11000862 Document Number: 6652
The comparative study of heavy and deuterium-depleted water on the vascular reactivity has shown significant changes of the basal tone in the smooth muscle of the rat thoracic aorta rings. While the heavy water induced relaxing effects, the deuterium-depleted water increased basal tone and vasoconstrictor responses at phenylephrin, noradrenalin and angiotensin. Endothelial nitric oxide seems to be involved in generating the muscular relaxing effects of heavy water.
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