Different effects of interleukin-1 on reactivity of arterial vessels isolated from various vascular beds in the rabbit
Robert, R.; Chapelain, B.; Néliat, G.
Circulatory Shock 40(2): 139-143
1993
ISSN/ISBN: 0092-6213 PMID: 8508518 Document Number: 408572
During septic shock, arterial smooth muscle is thought to be hyporeactive to vasoconstrictors. This hyporeactivity, however, seems to be different from one vascular bed to another. Interleukin-1 (IL-1), which is released during septic shock, might play a role in the different regional vascular responses to norepinephrine. Thus, the aim of the present study was to examine in vitro the effect of IL-1 on the response to norepinephrine of arteries isolated from different territories in the rabbit. Three types of responses were identified: IL-1 decreased NE-induced contraction by 54% in aorta, 42% in carotid artery, 54% in pulmonary artery, and 18% in renal artery; and IL-1 was devoid of significant effect in hepatic and mesenteric arteries; and IL-1 increased NE-induced contraction by 25% in femoral arteries. In conclusion, IL-1 might contribute to the regional blood flow abnormalities during septic shock.