Vascular alpha adrenotropic responses of the isolated rabbit kidney at 15 degrees C
Fonteles, M.C.; Karow, A.M.
Archives Internationales de Pharmacodynamie et de Therapie 227(2): 195-205
1977
ISSN/ISBN: 0003-9780 PMID: 199121 Document Number: 110277
Rabbit kidneys were isolated and perfused with a balanced salt solution at 15 degrees C. The effects of norepinephrine (NOR) and phentolamine (P) were tested after fastly or slowly induced cooling. Vascular alpha receptor effects were enhanced by a slow cooling rate (0.6 degrees C/min), but blocked or impaired by a faster cooling rate (6 degrees C/min). Kidney function was severely impaired at this temperature as it would be expected.