Association of the 463G-A myeloperoxidase gene polymorphism with gastric cancer risk
Jiang, Z.; Zhang, Z.; Wang, Z.; Zhang, G.; Hu, K.; He, B.; Wang, S.
Hepato-Gastroenterology 59(115): 757-761
2012
ISSN/ISBN: 0172-6390 PMID: 22094928 Document Number: 662830
To explore the association between polymorphism of myeloperoxidase (MPO) gene and the susceptibility to gastric cancer. A case control study of 117 gastric cancer patients and 105 controls was conducted to investigate the polymorphism of MPO gene 463G-A using the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The association between polymorphism and the risk of gastric cancer was examined by a multivariate analysis. Stratification analysis by age, gender, smoking status, H. pylori (Hp) infection and family history of gastric cancer was performed. In gastric cancer group the frequencies of the cases caring genotype G/G, G/A, A/A were 70.94%, 25.64% and 3.42%, respectively. In healthy control group, the frequency of genotype G/G, G/A, A/A was 51.43%, 37.14% and 11.43%, respectively. The frequency of genotype G/A and A/A in cancer group was found significantly higher than that in healthy control group (p<0.05). Compared with the MPO-463 G/G genotype, individuals with GA/AA genotype had a significantly decreased risk of gastric cancer (OR=0.50, 95%CI=0.28-0.90). In the stratification analysis, patients younger than 60 years old, male, Hp-IgG negative and with no family history of gastric cancer with genotype GA/AA had lower risk than those with genotype G/G. MPO gene polymorphism is associated with susceptibility of gastric cancer. It is conceivable that carriers of the A allele may be at reduced risk of gastric cancer.