Association of the IL-10 gene rs1800872 (-592 C>A) polymorphism with breast cancer in a Mexican population
Patricia Gallegos-Arreola, M.; Zúñiga González, G.Moisés.; Figuera, L.Eduardo.; Puebla Pérez, A.María.; Delgado Saucedo, J.Iván.
Journal of BUON Official Journal of the Balkan Union of Oncology 24(6): 2369-2376
2019
ISSN/ISBN: 1107-0625 PMID: 31983108 Document Number: 698951
Interleukin 10 (IL-10) gene polymorphisms are associated with different types of cancer, but these associations are inconsistent. The purpose of this study was to determine the frequency and association of the rs1800872 IL-10 gene polymorphism in Mexican women with breast cancer (BC). The rs1800872 polymorphism was genotyped in 368 BC patients and 320 control women using the polymerase chain reaction (PCR). The rs1800872 polymorphism was a risk factor for BC compared to controls and BC patients with genotypes CA (p=0.004) and AA, and in the recessive model (p=0.0002), dominant model (CA+AA; p=0.0001), and allele A ( p=0.0001). Additionally, differences were observed in BC patients with the CA and CAAA genotypes who had chemotherapy gastric and hematological toxicity (p=0.022) and tumor stage IV (p=0.013) as a risk factor. Genotypes were CA in breastfeeding (p=0.017), AA in gastric toxicity (p=0.048), and CAAA in tumor stage I-II (p=0.019) as protective risk factors. In BC carriers of: 1) CAAA genotype with tumor stage I-II and breast feeding (≥6 months), 2) CA genotype BC Luminal A with tumor stage I-II, 3) CA genotype BC Luminal B with breastfeeding (≥6 months), and 4) CAAA genotypes in BC HER2 with indices of cellular proliferation (Ki-67) that were elevated (≥20%), were considered to be protective factors in BC patients. The IL-10 gene rs1800872 polymorphism was associated with BC susceptibility in this sample from the Mexican population.