The G/C polymorphism of RAD51 gene in breast cancer
Romanowicz-Makowska, H.; Smolarz, B.; Kulig, A.
Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 21(121): 55-58
2006
ISSN/ISBN: 1426-9686 PMID: 17007294 Document Number: 597327
The development of breast cancer is associated with an accumulation of specific genetic alterations. The aim. In this study the distribution of G/G, G/C and C/C genotype and frequencies of the G and C allele of RAD51 G/C polymorphism in women with breast cancer was examined. 85 breast cancer samples were included in this study. They were categorised according to Scarf-Bloom-Richardson criteria in women with breast cancer. Blood samples age matched healthy individuals (n = 91) served as control. The distribution of the genotypes of the G/C polymorphism RAD51 in both control and patients did not differ significantly (p>0.05) from those predicted by the Hardy-Weinberg distribution. There were no significant differences in the genotype distributions and allele frequencies between node-positive and node-negative patients. Our study implies that it is possible that the G/C polymorphism of the RAD51 gene may not be directly involved in the development and/or progression of breast cancer but further researches, conducted on larger population, are needed to clarify this point.