Association of serum lipids and apolipoprotein E gene polymorphism with the risk of colorectal adenomas
Zhongyin, Z.; Hesheng, L.; Jun, L.; Jihong, C.
Saudi Medical Journal 27(2): 161-164
2006
ISSN/ISBN: 0379-5284 PMID: 16501668 Document Number: 601251
Objective: To investigate the relationship of serum lipids and apolipoprotein (apoE) gene polymorphism to colorectal adenomas.Methods: This study took place in the Department of Gastroenterology, Renmin Hospital of Wuhan University, PR China from June 2003 to March 2005. Ninety-eight patients with colorectal adenomas and 40 healthy subjects were enrolled, and their serum levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDLC) were determined. The apoE gene polymorphism was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results: Serum TC levels of colorectal adenomas group (5.32 +/- 0.85 mmol/L), distal colorectal adenomas group (5.58 +/- 0.63 mmol/L), and villous adenoma group (5.49 +/- 0.69 mmol/L) were higher than the control group (4.28 +/- 0.62 mmol/L, p=0.016), proximal colorectal adenomas group (4.82 +/- 0.58 mmol/L. p=0.038) and non-villous adenorna group (4.76 +/- 0.58 mmol/L, P=0.03). Serum HDL-C levels of colorectal adenomas group (1.39 +/- 0.25 mmol/L) were lower than the control group (1.51 +/- 0.29 rnmol/L) (p=0.035). Serum lipids levels of each genotype in colorectal adenomas group were not statistically significant. Apolipoprotem epsilon 3/epsilon 4 genotypic frequency in colorectal adenomas group (7.1%) was lower than the control group (17.5 %) (p=0.012).Conclusions: The findings suggest that altered lipid metabolism may be differentially associated with colorectal adenomas and the persons with apoE epsilon 3/epsilon 4 genotype have lower risk suffering from colorectal adenornas than those with other genotypes.