Increased INR from concomitant use of acenocoumarol and capecitabine
Tomlow, B.; Voll, M.L.; Smorenburg, C.H.
Nederlands Tijdschrift Voor Geneeskunde 156(26): A4793
2012
ISSN/ISBN: 1876-8784 PMID: 22759711 Document Number: 661291
A drug interaction between capecitabine and coumarin may result in an increased INR and bleeding complications. We describe an 80-year-old woman who presented with rectal bleeding and an increased INR due to the concomitant use of acenocoumarol and capecitabine for atrial fibrillation and metastatic cecal cancer, respectively. In patients with a compelling indication for treatment with capecitabine and anticoagulant therapy, conversion to low-molecular weight heparin should be considered.